Conference
Programme
Events will
be held in the halls of Electra Palace Hotel, unless otherwise indicated
Sunday,
19th September 2004
08:30-19:00 Registration
09:00-17:00 Education Course: Risks and benefits of
nutrition with respect to developmental toxicity
Chairs: John Bannigan,
09:00-09:25 The use of embryo cultures for teratological studies. The use of
the chick embryo
Prof. Dr. John Bannigan,
Dublin, Ireland
09:25-09:45 The use of rodent embryos in teratological
studies
Prof. Dr. Asher Ornoy,
Jerusalem, Israel
09:45-10:30 Antenatal diagnosis of human birth defects
by imaging techniques with emphasis on skeletal dysplasias
and neural tube defects
Dr. Apostolos Athanasiadis,
10:30-11:00 Coffee/tea
11:00-11:45 Genetic and nutritional interactions in the
etiology of birth defects
Assoc. Prof. Dr.
Maurizio Clementi, Padova, Italy
11:45-12:00 General discussion, J. Bannigan, A. Ornoy
and speakers
12:00-13:00 Lunch
13:00-13:45 Pregnancy: Risks and benefits of vitamin
supplementation/therapy
Prof. Dr. Richard K.
Miller, New York, USA
13:45-14:30 The beneficial role of vitamins and minerals in human
development and their toxicity
Prof. Dr. John M.
Tzafettas, Thessaloniki, Greece
14:30-15:00 Coffee/tea
15:00-15:45 Substances with endocrine activity in foods and in the
environment: Do they
cause developmental risks?
Dr. Alberto Mantovani,
Roma, Italy
15:45-16:30 Developmental
and reproductive toxicity of pesticides, dioxins and other environmental
pollutants. Exposure via nutrition
Prof. Dr. Ralf
Stahlmann, Berlin, Germany
16:30-17:00 General discussion, A. Ornoy, J. Bannigan
and speakers
19:00 Buses leave from Electra Palace Hotel for the Opening
Ceremony
19:30 Opening Ceremony (Main Aula of the
Welcome
Addresses
Introductory
Lecture: “Aristotle and Teratology”
Prof. of
Philosophy of Sciences Demetra Sfendoni-Mentzou,
Philharmonic Orchestra of the
Municipality of Thessaloniki
(Kind Participation)
21:00 Welcome Reception (Main Aula of the
Monday,
20th September 2004
08:00-19:00 Registration
09:00-12:00 Symposium: Diabetes in pregnancy and fetal development:
Clinical and experimental aspects
Coorganized with IFTS and supported by March of Dimes
Birth Defects Foundation,Grant No.4-FY03-150
Chairs:
Asher Ornoy,
Dimitrios Karamitsos,
09:00-09:30 The role of diabetes control in the prevention of congenital
malformations
Prof.
Dr. Dimitrios Karamitsos,
09:30-10:00 The developmental follow-up of children born to diabetic
mothers. The pediatricians view
Prof.
Dr. Asher Ornoy,
10:00-10:30 Oxidative
stress as a teratogen in diabetic pregnancy
Prof.
Dr. Ulf Eriksson,
10:30-11:00 Coffee/tea
11:00-11:30 Genetic versus environmental factors in
diabetes during prenatal life: Teratogenicity and
onset of the disease in the NOD model
Prof. Dr. Hiroki Otani, Izumo, Japan
11:30-12:00 The role of the placenta in diabetic
embryopathy
Prof. Dr. Richard K.
Miller, New York, USA
12:00-13:00 Lunch
13:00-16:00 Symposium: Detection and management of
genetic and environmentally produced thyroid disruption in neonates and
children. Supported by
Charles River Laboratories
Chairs: Alan
M. Hoberman,
S. Christian Horsham, PA,
13:00-13:30 Thyroid hormone and brain development:
Integrating information from molecular approaches yields basic and applied
insights to address risk analysis of potential thyroid toxicants.
Dr. Kelly Gauger, Amherst, MA, USA
13:30-14:00 Molecural defects in the hypothalamic-pituitary-thyroid axis
leading to congenital
hypothyroidism (CH)
Prof. Dr. Catherine
Dacou-Voutetakis, Athens, Greece
14:00-14:30 Neuropsychological outcome in children with prenatal and
perinatal thyroid hormone deficiencies. A model for
understanding thyroid hormone actions in human brain development
Dr. Joanne Rovet,
14:30-15:00 Coffee/tea
15:00-15:30 Thyroid and thyroid hormone levels in
non-clinical studies
Dr. Mildred S.
Christian, Horsham, PA, USA
15:30-16:00 US Environmental Protection Agency's screening and testing
program for endocrine disruptors
Dr. Elaine Z. Francis,
Washington, DC, USA
16:00-17:00 Free Communications
Chairs: Chryssi Kerameos-Foroglou,
and Frank Sullivan,
The role of oxidative stress in the etiology of fetal growth
restriction: A rat model
*Meytal Avgil, Roni Cohen, Asher
Ornoy
Hebrew University Hadassah Medical School, Jerusalem,
Israel
Investigation of toxic and teratogenic effects of anticoagulants on rat embryonic
development using in vitro culture method
*Ismihan Ilknur
Uysal1, Ahmet Kagan Karabulut1*, Kurtulus
Ozdemir2, Bulent Behlul Altunkeser2
Departments of 1Anatomy and 2Cardiology, Meram Medical
Faculty,
Postnatal viability of rabbit kits in peri- post-natal nonclinical
studies
*Mildred S. Christian1,
Elise M. Lewis2, Alan M. Hoberman2
1Argus
International, Inc.,
Does melatonin affect neurobehavioral
development of rats?
*M. Dubovický1, E. Ujházy1, P. Kovačovský2, J. Navarová1,
I. Juránek1
1Institute
of Experimental Pharmacology,
Sciences,
2Department of Psychology, Philosophical Faculty,
Comenius Universtity,
Morphological particularities in human race presented in art
and literature
*Maria Myrilla, Theodossis Papavramidis, Niki Papavramidou,
Maria Mironidou-Tzouveleki
Laboratory
of Pharmacology, Faculty of Medicine,
Discussion
17:00-19:00 Poster Session (with snacks and drinks)
20:30 Concert of the Symphony Orchestra
of the
Generously offered by the
Tuesday,
21st September 2004
08:00-18:00 Registration
08:30-11:00 Symposium: Antiretroviral drugs and
pregnancy
Supported by the Hellenic Association for the Study and
Control of
AIDS
Chairs: Elpida-Niki Emmanouil-Nikoloussi,
08:30-09:00 Risk assessment of ART and HAART in
pregnancy
Assoc. Prof. Dr. Elpida-Niki Emmanouil-Nikoloussi,
Thessaloniki, Greece
09:00-09:30 Antiretroviral therapy during pregnancy: The European
experience
Assoc. Prof. Dr. Maria
Theodoridou, Athens, Greece
09:30-10:00 Coffee/tea
10:00-10:30 Developmental toxicity of antiretroviral agents in experimental
animals
Prof. Dr. Ralf
Stahlmann, Berlin, Germany
10:30-11:00 The role of the placenta in fetal HIV
infection
Prof. Dr. Richard K.
Miller, New York, USA
11:15-12:45 Annual General Meeting of the ETS
12:45-13:45 Lunch
14:00-15:00 Free Communications
Chairs:
Maurizio Clementi,
Emmanouil- Nikoloussi,
The triazole triadimefon induces cranio-facial and axial
malformations in the mouse
*Elena Menegola, Maria Luisa Broccia, Francesca Di Renzo,
Valentina Massa, Erminio Giavini
Department of Biology, University of
Milan, Milan, Italy
Orthodontic treatment of cleft palate patients. Interaction
between
orthodontics and surgery
*Ioulia Ioannidou-Marathiotou
Department
of Orthodontics,
Congenital abnormalities in maternal epilepsy treated with
lamotrigine-valproate
combination:
Clinical assessment of a phenotype
ten Berg K1, Veenstra-Knol HE2, van Pinxteren-Nagler E3,
Engstrom LJ3,
*Lindhout D1
1DBG-Department
of Medical Genetics,
Genetics,
The effects
of 6-mercaptopurine on human first trimester trophoblast
explants
*Shelly Tartakover Matalon1, Asher Ornoy2, Ami Fishman3,
Michael
Lishner1
Oncogenetic
Laboratory, Department of Internal Medicine A1, and Department of Obstetrics
& Gynecology3, Sapir
Medical Center, Kfar Sava,
Israel; Sackler Faculty of Medicine, Tel-Aviv
University,
Laboratory
of Teratology, Department of Anatomy and Cell Biology,
Epithelial and germ cells kinetics in the developing testis in
embryos and neonates Wistar rat
*Marianthi Balla, Roxani
Angelopoulou
Department
of Histology and Embryology,
Discussion
15:00-15:20 Coffee/tea
15:20-16:15 Free Communications
Chairs:
The effects of indomethacin on chick embryonic
angiogenesis
Helen Lawlor, Aine
Dowling, *James Giles
Department of Human Anatomy and Physiology and Conway
Institute,
Population stratification in a case control association study of
hypospadias
*Jeanne Manson, Michael Carr
Histonedeacetylases
are new molecular targets whose inhibition can cause birth defects: Evidence
from structure-activity relationship of valproic acid
derivatives
*Daniel Eikel, Alfonso Lampen, Heinz
Nau
Centre for Systemic
Neuroscience, Department of Food Toxicology,
Interactions of protein, zinc, and carbon monoxide on skeletal
anomalies in
mice
Jarnail Singh*
Stillman College,
Tuscaloosa, Alabama, USA
Discussion
16:15-17:00 ETS Award Lecture: “A serendipitous journey from
acetazolamide (right) to
pitx2c (left)”
Prof. Dr. Nigel A.
Brown, London, UK
17:00-17:15 Presentation of the 33rd Conference of the
ETS
20:00 Conference Dinner (Electra Palace
Hotel)
Wednesday,
22nd September
08:00-16:00 Registration
09:00-12:00 Symposium: The new frontier: Developmental genes and
their application and uses
Co organized with the
Teratology Society
Chairs:
William Slikker, Jr,
Bannigan,
09:00-09:30 Experiences with a data set of toxicant-induced
transcriptional profiles
Dr. Mark D. Johnson,
Raritan, NJ, USA
09:30-10:00 Experimental design and interpretation of gene arrays in the
context of Developmental Toxicology
Prof. Dr.
Thomas Knudsen,
10:00-10:30 Developmental neurotoxicity: Assessment approaches
based on gene expression
Dr. William Slikker,
Jr., Jefferson, AR, USA
10:30-11:00 Coffee/tea
11:00-11:30 Expression of novel immunomodulators
(PIF) and proliferation controllers (DPS) by the embryo and by the placenta
Dr. Eytan R. Barnea,
11:30-12:00 Malformations and genetic defects of children born after
assisted reproduction
techniques
Assoc. Prof. Dr. Basil C. Tarlatzis,
Thessaloniki, USA
12:00-13:00 Lunch
13:00-15:30 Symposium: Inborn errors of metabolism and
teratology
Chairs: Jörn Oliver Sass,
Anastasios Manthos,Thessaloniki,
Greece
13:00-13:30 Inborn errors of metabolism and teratology:
An overview
Dr. Jörn Oliver
Sass, Freiburg, Germany
13:30-14:00 Inborn errors of metabolism: A clinician's
perspective
Dr. Philip J. Lee,
London, UK
14:00-14:30 Coffee/tea
14:30-15:00 Defects in cholesterol metabolism and abnormal embryonic
development
Dr. Francoise Gofflot,
Strasbourg, France
15:00-15:30 HELLP syndrome and LCHAD deficiency: fetal-maternal i
nteractions
Assoc. Prof. Dr. Persephone Augoustides-Savvopoulou,
Thessaloniki, Greece
15:30 Closing of Conference and
Farewell
POSTERS
1.
Kartagener's syndrome
Victor
Aivazis1, *Anastasia Kaouna1, Dimitrios Kasimos2, Eleni Maratou1, Athanasios
Hatzimichail2, Aikaterini KaidoglouAnagnostopoulou3
11st
Paediatric Department of Aristotle University of Thessaloniki, 2Paediatric
Department of Dimocritio University of Thrace, 3Laboratory of Histology Embryology and Anthropology of Aristotle
University of Thessaloniki Greece
2.
Disorders of the functional ability of the respiratory epithelium in children
with adenoidal hyperplasia
Victor
Aivazis1, Evangelia Bourli1, Eleni Maratou1, *Maria Lithoxopoulou1, Dimitra
Aivazi1, Eleni Foutzila1, Aikaterini KaidoglouAnagnostopoulou2, Georgios
Contzoglou3
11st
Paediatric Department of Aristotle University of Thessaloniki , 2Laboratory of
Histology Embryology and Anthropology of
Aristotle University of Thessaloniki,
3Otorynolarygology Clinic of Hippocratic Hospital of Thessaloniki Greece
3.
Micronucleus frequency in rat embryonic blood cell treated with anticoagulant
agents
*Melda
Aksoy1, Ismihan Ilknur Uysal2, Ahmet Kagan Karabulut2*, Kurtulus Ozdemir3,
Hasan Acar1, Bulent Behlul Altunkeser3
Departments
of 1Medical Biology and Genetics, 2Anatomy, 3Cardiology, Meram Medical Faculty,
Selcuk University, Konya, Turkey
4.
Oxidative damage affects dystrophin glycoprotein complex in x. Laevis primary
myogenesis
*Manuela
Andrioletti1, Umberto Fascio2, Paride Mantecca3, Marina Camatini3, Claudio
Vismara1
1Dipartimento
di Biologia, 2CIMA, Università degli Studi di Milano,Via Celoria 26,
Milano, Italia, 3Dipartimento di Scienze dell'Ambiente e del Territorio,
Università degli Studi di Milano-Bicocca, Piazza della Scienza 1,
Milano, Italia
5. Use of
IVOS automatized sperm analysis for detecting subtle spermatozoa changes in
rabbits during cyclophosphamide-induced toxicity
*Bégoud
L.1, Barbellion S.1, Lelong C.1, Charles P.2, Sarsat J.-P.1, Guittin P.1
1Drug
Safety Evaluation and 2Laboratory Animal Science and Welfare, Aventis, Vitry
sur Seine, France
6. Clinical
and genetic study of isolated cleft lip and isolated cleft palate versus
syndromes that associate cleft lip/cleft palate
*Lidia
Chircor, Chrisostomos Kapetanos
Department
of Anatomy, Faculty of General Medicine “Ovidius” University of Constanţa,
România
7.
Hydroxamic acid derivatives of valproic acid: Histonedacetylase inhibition and
pharmacokinetic profiles in mice
*Daniel
Eikel, Katrin Hoffmann, Alfonso Lampen, Heinz Nau
Centre for
Systemic Neuroscience, Department of Food Toxicology, School of Veterinary
Medicine Hanover, Germany
8. An
experimental study on teratogenic effects of ornidazole on mice skeleton
*Guven
Erbil, Kazim Tugyan, Bekir Ugur Ergur, Isil Tekmen, Cetin Pekcetin
Dokuz Eylul
University Medical Faculty, Histology & Embryology Department, Izmir,
Turkey
9. Multiple
congenital anomalies. A case report
Antonios
Filippopoulos, *Xenofon Sinopidis, Chrisostomos Kepertis, Georgios Koutsoumis,
Ekaterini Rammata, Euripides Prantsoudis, Menelaos Svirkos, Demetrios
Anagnostopoulos
Clinic of
Pediatric Surgery, G. Gennimatas Hospital, Aristotle University of
Thessaloniki, Greece
10.
Strategies to maintain and characterise the pluripotency of embryonic stem
cells
*Burkhard
Flick, Vivian Kral, Stephan Klug
Institute
of Clinical Pharmacology and Toxicology, Dept. of Toxicology,
Charité University Medicine
Berlin, Garystrasse 5, 14195 Berlin, Germany
11.
Ôhalidomide and hydroxyurea: their anti-apoptotic effect on regenerating rat
liver
Helen
Frangou-Massourides
Department
of General Biology, Medical School, Aristotle University of Thessaloniki,
Greece
12.
Topological changes in subcellular fractions of caspase-3 on human cervical
dysplasia and atrophy
*Helen
Frangou-Massourides, Sevasti
Massouridou, Alexander Kotsis
Department
of General Biology, Medical School, Aristotle University of Thessaloniki,
Greece
13. The
disturbance of the circadian systems induced by ethanol exposure in utero
*Yoshihiro
Fukui, Hiromi Sakata-Haga, Hiroyoshi Sei Kazuhiko Sawada
Department
of Anatomy and Developmental Neurobiology, University of Tokushima School of
Medicine Japan
14.
Sacroccygeal teratoma in term pregnacy
*H.
Giannoulis, T. Tantanasis, K. Papathanasiou, V. Vaitsi, I. Tzafettas
2nd
Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki,
Greece
15.
Multiple teratogenesis after use of isotretinoin during the first trimester of
pregnancy
*H.
Giannoulis, K. Papathanasiou, T. Tantanasis, V. Vaitsi, I. Tzafettas
2nd
Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki,
Greece
16. Cleft
lip and palate in south-east of Caspian Sea (North of Iran, Gorgan)
*Mohammad
Jafar Golalipour, Mohammad Hosian Tazik, Azad Reza Mansourian, Mahammad Ali
Vakili
Gorgan's
Congenital Malformation Research Center, Golestan University of Medical
Sciences, Gorgan, Iran
17. Neural
tube defects in newborns in Gorgan, North of Iran
*Mohammad Jafar
Golalipour, Mohammad Ali Vakili
Golestan
University of Medical Sciences, P.O. Box 49165-655, Gorgan, Iran
18. Effects
on reproductive organs and sexual development of rats perinatally exposed to
propiconazole: Preliminary results
Petya
Grigorova
National
Center of Hygiene, Medical Ecology and Nutrition, Sofia, Bulgaria
19.
Spontaneous variations and malformations in fetal cynomolgus monkey
*G.
Habermann, E. Buse, S. Friderichs-Gromoll, J. Kaspareit
Covance
Laboratories GmbH, Kesselfeld 29, 48163 Münster, Germany
20. Effects
of finasteride and DEHP on anogenital distance and nipple retention after
perinatal exposure in rats
*Ulla Hass,
Marta Filinska, Sofie Pedersen, Majken Dalgaard, Thuri S. A. Kledal
Department
of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary
Research, Søborg, Denmark
21.
Evaluation of potential teratogens in chick cardiomyocyte micromass cultures as
a prelude to comparing the effects on the differentiation of cardiomyocytes in
the d3 embryonic stem cell system
*Helena
Hurst, Margaret Pratten, Richard Clothier
FRAME
Alternatives Laboratories, School of Biomedical Sciences, University of
Nottingham, Nottingham, United Kingdom
22.
Quantitative gene expression analysis in mouse embryonic stem cells as an indicator
of embryotoxic potential
*Johanna
Kaltenhäuser, Elke Genschow+, Klaus Becker*
*Schering
AG, Research Laboratories, Berlin, +ZEBET, Berlin, Germany
23. Serum
reduced and serum free culture conditions for the embryonic stem cell test
*Stephan
Klug, Burkhard Flick
Institute
of Clinical Pharmacology and Toxicology, Dept. of Toxicology,
Charité Universitätsmedizin
Berlin, Garystrasse 5, 14195 Berlin, Germany
24.
Antiproliferative effect of bleaching agents against two established cell lines
Elizabeth
A. Koulaouzidou1, Konstantinos T. Papazisis2, Nikolaos Economides3, Artemis
Karanika-Kouma1, Alexander H. Kortsaris4
Departments
of 1Operative Dentistry and 3Endodontology, Dental School, Aristotle University
Thessaloniki, 2Theagenion Cancer Institute and 4Department of Biochemistry,
Medical School, Democretian University of Thrace, Greece
25. The
influence of genetic factors in the pathogenesis of multiple sclerosis (MS)
Kountouris
D., Koutsobelis K.
Neurological
Diagnostic Center, Athens, Greece
26. Toxicity
to reproduction: From animals to humans
*Leda
Kovatsi, Heleni Tsoukali
Laboratory
of Forensic Medicine & Toxicology, School of Medicine, Aristotle University
of Thessaloniki, Thessaloniki, Greece
27.
Differential gene profiles in developing embryo and fetus after in utero
exposure to ethanol
*Rhee Da
Lee, Sang Mi An, Gyu Seek Rhee, Soon Sun Kim, Seung Jun Kwack, Ji Hyun Seok,
Soo Yeong Chae, Dae Hyun Cho, Kui Lea Park
National
Institute of Toxicological Research, Korea Food & Drug Administration,5,
Nokbun-dong, Eunpyung-gu, Seoul, 122-704, Korea
28. The
effects of soy-derived isoflavones and a high fat diet on spontaneous mammary
tumor development in Tg.NK (MMTV/C-neu) mice
*Mirjam
Luijten1, Anni Rønfeldt Thomsen3, Jolanda A.H. van den Berg1, Piet W.
Wester1, Aart Verhoef1, Nico J.D. Nagelkerke2, Herman Adlercreutz4, Henk J. van
Kranen1, Aldert H. Piersma1*, Ilona K. Sørensen3, Ghanta N. Rao5 (†),
Coen F. van Kreijl1
1Laboratory
of Toxicology, Pathology, and Genetics, and 2Centre for Information Technology
and Methodology, National Institute for Public Health and the Environment,
Bilthoven, The Netherlands, 3Danish Institute for Food and Veterinary Research,
Department of Toxicology and Risk Assessment, Mørkhøj Bygade 19,
2860 Søborg, Denmark, 4Institute for Preventive Medicine, Nutrition, and
Cancer, Folkhälsan Research Center, and Division of Clinical Chemistry,
University of Helsinki, Finland, 5National Institute of Environmental Health
Sciences, NIH, P.O. Box 12233 MD B3-08, Research Triangle Park, USA (deceased)
29.
Assessment of new drugs with potential CNS activity in juvenile rats
*SR
Maguire, J Ridings, M Parkinson, HM Solomon, DJ Stanislaus, RL Clark
GlaxoSmithKline,
Herts SG12 ODP, United Kingdom
30. A
systematic, register-based surveillance system for assessing drug safety during
pregnancy
*Heli
Malm,1 Mika Gissler,2 Timo Klaukka,3 Joanna McCormack,2 Jouni Meriläinen,2
Olli Nylander,2 Mareena Paldán,3 Erkki Palva,4 Annukka Ritvanen,2
Kristiina Tyrkkö,3 Jyrki Vanakoski4
1
Teratology Information Service and Department of Clinical Pharmacology,
Helsinki University Central Hospital, Helsinki, Finland; 2National Research and
Development Centre for Welfare and Health (STAKES), Finland; 3 Social Insurance
Institution (KELA), Finland; 4 National Agency for Medicines, Finland
31. S100
protein expression in Balb/c mouse brain development after valproic acid
administration
*Manthou
M.-E., Emmanouil-Nikoloussi E.-N., Nikoloussis E., Papamitsou Th.,
Andriopoulou-Economou L., Manthos A.
Laboratory
of Histology-Embryology & Anthropology, Faculty of Medicine, Aristotle
University of Thessaloniki, 541 24 Thessaloniki, Greece
32.
Gene-expression analysis of VPA-induced skeletal malformations
*Massa V.1,
Menegola E.1, Cabrera R.M.2, Giavini E.1, Finnell R.H.2
1Department
of Biology, University of Milan, Milan, Italy,
2Institute of Biosciences and Technology, Texas A&M University
System Health Science Center, Houston, USA
33. Early
diagnosis of acardius trap sequence
*Stephanos
Milias, Georgia Karayanopoulou, Georgios Karkavelas, Antonios Drevelegas1,
Constantine S. Papadimitriou
Department
of Pathology and 1Department of Radiology, Aristotle University, Medical School
of Thessaloniki, Greece
34. Study
on the developmental toxicity of some drugs using rat and hamster lb/cns
micromass cultures
*Maria
Minta, Iwona Wilk, Jan Żmudzki
Department
of Pharmacology and Toxicology, National Veterinary Research Institute, Pulawy,
Poland
35.
Relation between leptin and insulin in patients with type II diabetes mellitus
Javad
Mohiti, Mohammad Afkhami and Hajar Sedghi
Yazd
Diabeties Research Center, Shahid Sadoughi University of Medical Science, Yazd,
Iran
36. Effect
of antioxidants on biochemical changes induced by phenytoin in pre- and
postnatal development of rats
*J.
Navarová, E.Ujházy, M. Dubovický, M. Mach
Institute
of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia
37.
Famciclovir exposure during organogenesis
Polyxene
Neou1, Yolanta Gyftodemou2, Electra Valti1, Athina Tsamadou1, Vassiliki
Sofidiotou1
1Teratogen
Information Center, Children's Hospital P&A Kyriakou, Athens, Greece,
2Institute of Child Health (Genetic Dept.), Children's Hospital Agia Sofia,
Athens, Greece
38.
Immunohistochemical identification of hematopoietic stem cells (HSC) and
dendritic cells (DC) during thymus development
defined by S100 protein expression
in Balb/c mice embryos after
valproic acid administration
*Nikoloussis
E., Emmanouil-Nikoloussi E.-N., Manthou M.-E., Papamitsou Th., Manthos A.
Laboratory
of Histology-Embryology & Anthropology, Faculty of Medicine, Aristotle
University of Thessaloniki, 541 24 Thessaloniki, Greece
39.
Neurodevelopment in children exposed in utero to cyclosporine and azathioprine
following maternal renal transplant: preliminary results
*Irena
Nulman1, Michael Sgro2, Maru Barrera3, David Chitayat4, Gideon Koren1
1Motherisk,
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children,
University of Toronto; 2Department of Pediatrics, St-Michael Hospital,
University of Toronto; 3Division of Psychology, The Hospital for Sick Children,
University of Toronto; 4Division of Genetics, Toronto General Hospital,
University of Toronto, Toronto, Ontario, Canada
40.
Immunohistochemical study of estrogen receptors alpha in rat fetal kidney and
ureter
Theodora Papamitsou,
Stella Makri-Patsala, Dorothea Kapoukranidou, Louiza Ekonomou, Paraskevi
Papaioannidou
Medical
Department, Aristotelian University of Thessaloniki, Greece
41.
Optimisation of food allotment for New Zealand white rabbits in embryo fetal
development studies
*Jacqui
Piner, Meg Parkinson
GlaxoSmithKline,
General and Reproductive Toxicology, Park Road, Ware, Hertfordshire, UK
42. The
apoptotic activity in the femoral rat cartilaginous bone and its relation to
the growth rate during neonatal age
*Avraam
Ploumis1,2, Maria-Eleni Manthou1, Elpida-Niki Emmanouil-Nikoloussi1, Sofia
Androudi1, Anastasios Christodoulou2
1Laboratory
of Histology-Embryology and Anthropology, Aristotle University Medical School,
Thessaloniki, Greece, 21st Orthopaedic Department, Aristotle University Medical
School, Thessaloniki, Greece
43.
Antifungal triadimefon effects on the development of Xenopus laevis embryo:
Analysis of the alterations at the branchial apparatus
*Mariangela
Prati, Rosalba Gornati, Giovanni Bernardini
Department
of Structural and Functional Biology, Insubria University, Via J.H. Dunant, 3,
Varese, Italy
44. Not all
developmental toxicity studies require dosing during pregnancy
Luc De
Schaepdrijver, Katelijne Anciaux, Jan Fransen, Graham Bailey, Eric De Waal,
Patrick Sterkens, Lieve Lammens, Werner Coussement
Global
Preclinical Development, Johnson & Johnson Pharmaceutical Research and
Development, a division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340
Beerse, Belgium
45. Zinc
supplementation increases fetal zinc concentration in protein-deficient CO
exposed mice
*Jarnail
Singh1, Yasmin H. Neggers2
1Stillman
College, 2Department of Human Environment, the University of Alabama,
Tuscaloosa, Alabama, USA
46.
Genotoxic effect of anti-HIV drug zidovudine on human hepatoma cells HepG2 and
human colonic cells Caco-2
*Darina
Slameňová 1, Eva Horváthová 1, Miriam
Bartková1, Elena Szabová2
1Cancer Research Institute, the Slovak Academy
of Sciences, 833 91 Bratislava, Slovak Republic, 2Research Base of the Slovak
Medical University, 833 03 Bratislava, Slovak Republic
47.
Occupational exposures and birth defects in Slovak Republic
* Elena
Szabová 1, Dagmar Zeljenková 1, Jaroslav Černy2, the ORFCOM
collaborative group3
1Research
Base of the Slovak Medical University-Institute of Preventive and Clinical
Medicine, Bratislava, Slovakia, 2Institute of Zoology SAS, Bratislava,
Slovakia, 3Members of the ORFCOM collaborative group: E. Véghová,
S. Plačková, D. Brašeňová, E.
Nesčáková, A. Číková, E.
Bieliková,E. Horáková, D. Mračnová., I.
Kolosziová, R. Sečkárová, M. Borgulová, I.
Moravcová, P. Košík, M. Kvasnicová, E.
Čarnoká, M. Molčáková, H. Sedláčková,
D. Dragijská, N. Mišovicová, M. Hodálová, E.
Koubeková, V. Ostatník, E. Nemcová, K.
Tancárová, J.
Juričová, J. Koblík, Šmelková, K.
Tancárová, M. Sopková, Pšeničková, K.
Sterczová, M. Vasil, E. Nebesňáková, O.
Pirochová, E. Gnothová
48.
Developmental immunotoxicity of dexamethasone: Comparison with effects induced
by maternal toxicity
*Mariska M.
Tegelenbosch-Schouten, André P. Wolterbeek, Ine D. Waalkens-Berendsen,
Anja Dijkstra, Frieke Kuper, Maaike van Zijverden, Elles I. Klein Koerkamp,
André H. Penninks
TNO
Nutrition and Food Research, Zeist, The Netherlands
49. Safety
evaluation of cosmetics and cosmeceuticals with respect to developmental and
reproductive toxicity: A review
Georg
Tzimas
Cosmetology
Center Tzimas, Edessis 2, GR-546 25 Thessaloniki, Greece
50. Effect
of pyridoindol stobadine on maternal and embryofoetal toxicity in rats due to
intrauterine hypoxia induced by phenytoin administration
*E.
Ujházy1, M. Mach1, M. Dubovický1, J. Navarová1, I.
Juránek1, I. Brucknerová2
1Institute
of Experimental Pharmacology, Slovak Academy of Sciences, 21st Children's
Hospital School of Medicine, Comenius University, Bratislava, Slovakia
51. The
effects of electromagnetic fields on embryonic development: Morphological
investigations on rat embryos cultured in vitro
*Ismihan
Ilknur Uysal1, Ilhami Celik2, Ahmet Salbacak1, Ahmet Kagan Karabulut1, Refik
Soylu3, Yasemin Oznurlu2
Departments
of 1Anatomy and 3Histology and
Embryology, Meram Medical Faculty, Department of Histology, Veterinary Faculty,
Selcuk University, Konya, Turkey
52. General
evaluation of selective screening for amino acids analysis in plasma and/ or urine
performed in the 1st Laboratory of Genetic Explorations of Cluj county
hospital, Romania, between 1980 and 2003
*Romana
Vulturar1, Ileana Benga2, Gheorghe Benga1,3
1Department
of Cell and Molecular Biology, “Iuliu Haţieganu” University of Medicine
and Pharmacy, Cluj-Napoca, Romania, 2Department of Pediatric Neurology of
“Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Child
Neuro-Psychiatry Clinic of Cluj Children Hospital, Romania, 31st Laboratory of
Genetic Explorations of Cluj County Hospital, Romania
53. Impact
of maternal toxicity on pre- and postnatal development of rats
André
P. Wolterbeek, *Mariska M. Tegelenbosch-Schouten, Ine D. Waalkens-Berendsen,
Anja Dijkstra
TNO
Nutrition and Food Research, Zeist, The Netherlands
54. The
male rabbit as test species in male fertility studies
*T.D. Yih1,
A.J. Grootenhuis2
Organon,
1Department of Toxicology and Drug Disposition, 2Department of Pharmacology,
P.O. Box 20, 5340 BH Oss, The Netherlands
55.
Population variation of human mitochondrial DNA hypervariable regions I and II
in 100 Egyptian individuals demonstrated by DNA sequencing analysis
*Essam A.
Zaki 1, Abdel Ghany A. Abdel Ghany2
1Department
of Nucleic Acids Research, Genetic Engineering & Biotechnology Research
Institute (GEBRI), Mubarak City for Scientific Research, Research Area, Borg El
Arab, Post Code 21934, Alexandria, Egypt, 2Institute of Efficient Productivity,
El Zagazig University, El Zagazig, Egypt
56.
Anticancer drugs: Comparative in vitro and in vivo embryotoxicity studies
*Sara
Zanoncelli, Monica Longo, Debora Manera, Luigi Pietro Meroni, Kjell Gunnarsson,
Marco Brughera
Department
of Discovery and Development Toxicology, Pharmacia Italia S.p.A, subsidiary of
Pfizer Inc., Nerviano (Milano), Italy
57.
Possible estrogenic effect of formaldehyde
Dagmar
Zeljenkova, Elena Szabova
Research
base of the Slovak Medical University -Institute of Preventive and Clinical
Medicine, Bratislava, Slovak Republic
Late Abstracts
58.
Infection with mycoplasma and orofacial cleft in newborn infants in Slovakia
1Agatha
Molnarova*, 2Elena Kovacova, 3 Elena Horakova , 4Jozef Fedeles, 4 Jan
Vojtassak, 4 Vanda Repiska
1Department
of Plastic Surgery, Medical Faculty of Comenius University, Hospital Ruzinov,
Bratislava,
Slovakia, 2Institute of Virology, Slovak Academy of Sciences, Bratislava,
Slovakia
3Department
of Gynecology, Medical Faculty of Comenius University, Hospital Ruzinov,
Bratislava,
Slovakia, 4Institute of Medical Biology and Genetics, Medical Faculty of
Comenius University, Bratislava, Slovakia
59.
Papiloma Virus (HPV) and the cytomorphological changes that can help in the
development of the intraepitelial neoplasis (CIN)
Elsa Kone,
Xheladin Çeka
Department
of Morphology, Faculty of Medicine, Tirana, Albania
60. Some
hematological indexes in the pregnant women of the rural areas of the Central
and Southern Albania
1Xheladin
Çeka,1Elsa Kone,2Nexhmije Çeka
1Department
of Morphology, Faculty of Medicine, Tirana, Albania, 2Specialist of information
technology
61. Low
TGF-b expression in the fibroblastic cells of a cyclopic dysmorphic fetus
P.
Ctena-Agapitou, P. Dimou, E. Agapitos, E. Patsouris, Department of Pathology,
Medical School, University of Athens, Greece
62.
Oxidative stress regulates the expression and activity of transcription factor
activator protein-1 in rat conceptus
E. Zadorin,
K. Shevchenko
National
Medical University, Kiev, Ukraine
63. A mouse
model for valproate teratogenicity: Parental effects, homeotic transformations,
and altered HOX expression
Zadorin E,
Shevchenko K.
National
Medical University, Kiev, Ukraine, Ukrainian Biochemical Society, Kiev, Ukraine
64.
Teratogenic effects of CKD-602, a new camptothecin anticancer agent, in rats
Moon-Koo
Chung, Sung-Soo Baek, Sang-Seop Han
Korea
Institute of Toxicology, KRICT, Daejeon 305-600, Republic of Korea
65.
Treatment- related determinants of combined triazoles prenatal toxicity
Maria
Zouka, Petya Grigorova, Tatjana Vergieva
Lab of
Long-term effects,NCHMEN, Sofia,Bulgaria
Conference
Prizes
This year,
three prizes will be issued for young scientists. The ETS prize (500 €) and two
further prizes, awarded by Elsevier, will be given for the best free communication
and/or poster presented by members of the ETS or those who have applied for
membership before the Conference. The names of the winners will be announced at
the Conference Dinner.
Getting
to Makedonia Airport
Makedonia
Airport of Thessaloniki is located 20 km from the centre of the city. The most
convenient way of getting from your hotel to the airport is to take a taxi. The taxi ride takes about
30 minutes and costs approximately 10.00 €, both depending on the traffic.
There is
also an express bus from the Centre of Thessaloniki to the airport (line 78,
departs every 30 min, fare 0.45 €, travel time of about 50 min). Tickets are
available at ticket vending machines. The nearest stop to all hotels is
Aristotle Square.
Social
Programme
For details
and booking, contact the Conference Secretariat.
20
September 2004
Guided City
Tour. Price per person: 25 Euro, minimum
participation 15 persons
We will see
the White Tower, the Arch of Gallerius, the Rotonda, the Walls and the
Acropolis, the Ancient Agora (market place) and some of the most impressive
Byzantine churches of the city (duration 3 hours).
Museum of
Byzantine Culture. Price per person: 15 Euro, minimum participation 15 persons
(duration 2
hours).
Post-Conference
Tours
23
September 2004
Vergina.
Price per person: 35 Euro, minimum
participation 15 persons
We will
visit Vergina, the First capital city of the ancient Macedonia, and view the
impressive Macedonian tombs with their invaluable treasures (travel by bus,
lunch is scheduled, price not included)
Mount Athos
Cruise. Price per person: 60 Euro, minimum participation 15 persons
By
boat. All along the western coast,we
will observe the unique republic of
monks with its impressive byzantine monasteries (all- day tour, lunch is
scheduled, price not included).
Money and
Foreign Exchange
Greece's
currency is the Euro. Other currencies can be changed at the airport, banks and
hotels.
Public
Transportation
Transportation
in the city is provided by buses and taxis.
Radio Taxi
Phone Numbers: 2310525000, 2310550500, 2310555112, 2310214900, 2310218600,
2310886770
Weather
The weather
in Thessaloniki and its surroundings is mild and sunny during September
(average air temperature 25-29ºC, sea temperature 24-26ºC, sunshine
duration 11 hours/day, relative humidity 58%). For on-line weather information,
visit www.weatheronline.co.uk/Greece/Thessaloniki.html.
Insurance
Please,
note that it is the responsibility of the participants to insure against loss,
accidents and damage occurring during the Conference, including social events,
and post-conference activities.
Acceptance
of auspices does not mean or imply cooperation with religious or political
associations.